UK health authority approves HIV-1 long acting injectable combo Cabotegravir, Rilpivirine

UNITED Kingdom’s health products regulator, the Institute of Health and Care Excellence (NICE) approved the use of cabotegravir and rilpivirine in UK, issuing a draft guidance for the use of this long acting injectable treatment.
In a statement, NICE said recommends this treatment for HIV-1 infection in adults.
“Today’s draft guidance is the first time NICE has made recommendations about the use of an HIV treatment since these came under NICE’s remit in 2019.

“It is estimated that around 13,000 people will now be eligible for treatment with cabotegravir with rilpivirine in England,” read the statement.

The treatment is given after every two months.
“Clinical trial results show that cabotegravir with rilpivirine is as effective as oral antiretrovirals at keeping the viral load low.
Both cabotegravir and rilpivirine are administered as 2 separate injections every 2 months, after an initial oral (tablet) lead-in period,” explaines NICE.
Meindert Boysen, deputy chief executive and director of the Centre for Health Technology Assessment at NICE, said: “Despite scientific advances HIV is still incurable, but the virus can be controlled by modern treatment. However, for some people, having to take daily multi-tablet regimens can be difficult because of drug-related side effects, toxicity, and other psychosocial issues such as stigma or changes in lifestyle. The committee heard that stigma remains an issue for people living with HIV and can have a negative impact on people’s health and relationships.
“We’re pleased therefore to be able to recommend cabotegravir with rilpivirine as a valuable treatment option for people who already have good levels of adherence to daily tablets, but who might prefer an injectable regimen with less frequent dosing.”

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